Artem tcherkassov

Artem tcherkassov. However, a notable drawback of a binary representation of interaction data is that missing endpoints for Artem Tcherkassov Paul S. Nov 27, 2023 · Rakovina Therapeutics Inc (TSX-V:RKV) on Monday announced the appointment of Professor Artem Cherkasov to its Scientific Advisory Board (SAB). Artem Cherkasov to the Company’s Scientific Advisory Board. Artem Tcherkassov participated in the Third Vancouver International Mining Conference on the margins of AME BC's Mineral Liked by Olexandr Isayev. Artem Cherkasov is a Tier 1 Canada Research Chair in Precision Cancer Drug Design. Artem received a PhD degree from Kazan University and a Doctor of Science degree Alexander Tropsha 1, Olexandr Isayev 2, Alexandre Varnek 3, Gisbert Schneider 4 & Artem Cherkasov 5,6 Abstract Quantitativestructure–activityrelationship(QSAR)modelling, Mar 13, 2012 · Page 1499. acherkasov@prostatecentre. I. Figure 1 caption, second line, the PDB code for 1 “3VIS” should be “3V1S”. Rennie Fuqiang Ban Eric J. Nov 15, 2014 · January 29th, 2014: The Honorary Consul of the Russian Federation Dr. org. El Paso, TX 79968-0587 Nov 27, 2023 · VANCOUVER, British Columbia, Nov. Sep 24, 2022 · 3. Artem Cherkasov Professor of Medicine, University of British Columbia 2y Report this post Vancouver Prostate Centre 933 followers 2y Congratulations to Dr Artem Cherkasov's 4 research works with 88 citations and 32 reads, including: ChemInform Abstract: A New Method for Estimation of Homolytic CH Bond Dissociation Enthalpies Increased multiple antibiotic resistance in the face of declining antibiotic discovery is one of society’s most pressing health issues. Cox, Artem Cherkasov, Jaideep Chaudhary 5e. Variational autoencoders (VAEs) defined over SMILES string and graph-based representations of molecules promise to improve the optimization of molecular properties, thereby revolutionizing the pharmaceuticals and materials industries. 63430. While virtual docking can significantly accelerate the process of drug discovery, it ultimately lags the current rate of expansion of chemical databases that already exceed billions of molecular records. Dr. Artem Cherkasov performed in silico screening of 150 million compounds to identify drugs targeting the AR DBD . Nov 27, 2023 · VANCOUVER, British Columbia, Nov. Computer-Aided Drug Discovery of Novel Cancer Drugs. University Ave. Quantitative structure-activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is widely used in computer-aided drug design. But professors Artem Cherkasov and Olexandr Isayev were surprised to find that no recent academic papers provided a comprehensive, global research review of how deep learning and GPU-accelerated computing impact drug Read Article May 2015. He is a professor in the Department of Urologic Sciences at the University of British Columbia and senior scientist at the Vancouver Prostate Centre. Canada Research Chair in Precision Cancer Drug Design. Jan 12, 2022 · Dr. Artem Cherkasov Vancouver Prostate Centre, UBC acherkasov@prostatecentre. Thus, newer Abstract. Artem Cherkasov’s Post Artem Cherkasov Professor of Medicine, University of British Columbia 3mo Report this post Happy to announce that we won CACHE1 conpetition (tied for the 1st place). Learn More. However, all current anti-androgens directly interact with the AR at the androgen binding site, which is prone to resistant mutations, calling for new strategies of the AR inhibition. com. com Abstract Variational autoencoders (VAEs) deﬁned over SMILES string (simpliﬁed molecular-input line-entry system) and graph-based representations of molecules promise Artem Cherkasov The mutation-driven transformation of clinically used anti-androgens into agonists of human androgen receptor (AR) represents a major challenge in the current treatment of prostate May 30, 2019 · All SMILES Variational Autoencoder. (TSX-V: RKV) (“the Company”), a biopharmaceutical company focused on the development of novel DNA-damage response inhibitors (DDRi) to . View. com Jason Tyler Rolfe Quadrant jason@quadrant. Antimicrobial peptides represent a promising new class of antibiotics. Facebook gives people the power to share and makes the world more open and connected. Prof. For more information about our Therapeutics Development Services and how we might help you, please contact: Dr. Tel: 604-822-2644 Cell: 604-209-3048 Email: erik. Cherkasov’s research interests include artificial intelligence (AI) and computer-aided drug discovery (CADD), structure-activity modelling, drug reprofiling Jun 26, 2014 · Quantitative structure-activity relationship modeling is one of the major computational tools employed in medicinal chemistry. Alternate Contact. Artem Cherkasov sees things. Wednesday, February 21, 2024 Artem Cherkasov, North-Caucasus Federal university, Department of foreign history, political studies and international relations, Graduate Student. A full list of this year's awardees has been posted by the UBC Faculty of Medicine. Join Facebook to connect with Artem Cherkasov and others you may know. Nada Lallous. Play over 320 million tracks for free on SoundCloud. We previously identified a druggable pocket on the DNA binding domain (DBD) dimerization surface of the AR Nov 27, 2023 · VANCOUVER, British Columbia, Nov. Jan 6, 2014 · QSAR modeling is widely practiced in academy, industry, and government institutions around the world. Whereas, the majority produce amino terminal-truncated ERG proteins, all retain the C-terminal DNA-binding ETS domain []. Transcription factors (TFs) act as major oncodrivers in many cancers and are frequently regarded as high-value therapeutic targets. Jul 25, 2018 · In silico drug-target interaction (DTI) prediction is an important and challenging problem in biomedical research with a huge potential benefit to the pharmaceutical industry and patients. Here we ask whether it is possible to make small broad spectrum peptides employing minimal assumptions, by capitalizing on accumulating chemical biology information. However, these VAEs are hindered by the Drug discovery is a rigorous process that requires billion dollars of investments and decades of research to bring a molecule “from bench to a bedside”. Email: Click here to contact Dr. Professor Artem Cherkasov is looking for a talented Postdoctoral Research Fellow with a demonstrated research background in machine learning to join his computer-aided drug design group. The roles of Lin28A and Lin28B in cancer development and progression have been elucidated over the last decade. Cherkasov’s research interests include artificial intelligence (AI) and computer-aided drug discovery (CADD), structure-activity modelling, drug reprofiling Add open access links from to the list of external document links (if available). PERFORMING ORGANIZATION REPORT NUMBER University of Texas at El Paso 500 W. TASK NUMBER E-Mail: mbcox@utep. As the AR DBD is shared between AR-FL, AR-LBD mutations, and AR-Vs, such an approach is likely to target all forms of the AR. · Location: Pittsburgh. This recent surge of small Official tennis player profile of Andrei Cherkasov on the ATP Tour. 500+ connections on LinkedIn. In recent years, progress in artificial intelligence techniques, such as deep learning, the rapid growth of databases of molecules for virtual screening and dramatic improvements in Jan 18, 2024 · Dr Artem Cherkasov's success in winning the worldwide drug discovery challenge is praiseworthy. J. The ‘Big Bang’ of the chemical universe. 69628. Some examples include: - Know a lot about capacity management: have expanded own delivery network Artem Cherkasov’s Post Artem Cherkasov Professor of Medicine, University of British Columbia 4mo Report this post Excited to share our latest review in NRDD: Nov 27, 2023 · Rakovina Therapeutics Inc. Not that you’d know it from his business card: Associate Professor with the UBC Department of Urologic Sciences and Senior Research Scientist with the Vancouver Prostate Centre. Modern drug discovery relies upon intelligent exploration of ‘in stock’ and ‘on demand’ virtual libraries of compounds. edu, acherkasov@prostatecentre. Artem Cherkasov's 3 research works with 120 citations and 695 reads, including: Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms. However, these VAEs are hindered by the non-unique nature of SMILES strings and the computational cost of graph Apr 18, 2017 · Abstract. Data-driven professional with 7+ years of experience in product management, business development and analytics. His research interests include computer-aided drug discovery (CADD), structure-activity modeling, drug reprofiling, new cancer Artem Cherkasov is a Tier 1 Canada Research Chair In Drug Discovery at Canada Research Chairs based in Ottawa, Ontario. ai Abstract Variational autoencoders (VAEs) deﬁned over SMILES string and graph-based representations of molecules promise to improve the optimization of molecular Mar 27, 2024 · The Company has entered into a collaboration agreement (“Agreement”) with Dr. ca Artem Cherkasov Jankovic Bojana On the basis of the inductive QSAR descriptors we have created a neural network-based solution enabling quantification of antibacterial activity in the series of Jun 22, 2022 · It may seem intuitive that AI and deep learning can speed up workflows — including novel drug discovery, a typically years-long and several-billion-dollar endeavor. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. Mar 3, 2022 · Deep learning methods have in recent years shown promising results in characterizing proteins and extracting complex sequence–structure–function relationships. 172 by The AI Podcast on desktop and mobile. Artem Cherkasov, North-Caucasus Federal university, Department of foreign history, political studies and international relations, Graduate Student. Artem Cherkasov to the Company's Scientific Advisory Board Mar 19, 2024 · Proteolysis-targeting chimeras (PROTACs) that engage two biological targets at once are a promising technology in degrading clinically relevant protein targets. Reports to: PI and Clinical Trials Manager. While one family member, ERG, has been rigorously studied in the context of prostate cancer where it plays a critical role, other ETS factors keep emerging as potential hallmark oncodrivers. The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. View Olexandr Isayev Artem Cherkasov. His research interests include computer-aided drug discovery (CADD), structure-activity modeling, drug reprofiling, new cancer therapeutics discovery and Dr. The Postdoctoral Fellow will work on exciting drug discovery programs providing cutting-edge deep learning docking strategy to support structure-based and Jan 12, 2022 · Dr. Research interests include computer-aided drug discovery (CADD), QSAR modeling, drug reprofiling and development of new cancer therapies. There are numerous TMPRSS2-ERG fusions that encode for ERG transcripts. Cherlasov. Artem Cherkasov granting Rakovina exclusive access to the proprietary Deep Docking (trademarked) AI Platform for Dec 8, 2023 · Key advances in the field are described, including deep generative and reinforcement learning approaches in molecular design, deep learning models for synthetic planning and the application of deep QSAR models in structure-based virtual screening. Artem Cherkasov is a Professor in the Department of Urologic Sciences, Faculty of Medicine at the University of British Columbia, and Senior Scientist at the Vancouver Prostate Centre. Variational autoencoders (VAEs) defined over SMILES string and graph-based representations of molecules promise to improve Jul 25, 2018 · PADME: A Deep Learning-based Framework for Drug-Target Interaction Prediction. May 30, 2019 · All SMILES VAE. , a biopharmaceutical company focused on the development of novel DNA-damage response inhibitors to address high unmet Jun 22, 2022 · Play Artem Cherkasov and Olexandr Isayev on Democratizing Drug Discovery with Deep Learning - Ep. However, throughout its entire history it has drawn both praise and criticism concerning its reliability, limitations, successes, and failures. 27, 2023 (GLOBE NEWSWIRE) -- Rakovina Therapeutics Inc. Tier 1 - 2021-06-01. CARABET Nada LALLOUS Kriti SINGH Helene MORIN Anh-Tien TON Original Assignee The University Of British Columbia Priority date (The priority date is an assumption and is not a legal conclusion. WORK UNIT NUMBER AND ADDRESS(ES) 8. In silico drug-target interaction (DTI) prediction is an important and challenging problem in biomedical research with a huge potential benefit to the pharmaceutical industry and patients. 27, 2023 (GLOBE NEWSWIRE) — Rakovina Therapeutics Inc. Somasekharan has been granted a $1. css"> Please enable JavaScript to continue using this application. View bio for Dr. One method includes obtaining a screen definition for a screen, where the screen includes a cell-based assay that is run on a temporarily contiguous basis using a plurality of multi-well plates. Zaccary Alperstein, Artem Cherkasov, Jason Tyler Rolfe. Tel: 604-875-4111 ext. The ETS family of proteins consists of 28 transcription factors, many of which have been implicated in development and progression of a variety of cancers. com Jason Tyler Rolfe D-Wave Systems jrolfe@dwavesys. Ideas. To address this expansion of the accessible chemical universe, molecular docking needs to accurately rank billions of chemical stru The Vancouver Prostate Centre (VPC) has an exceptional opportunity available for a temporary, full-time Clinical Trials Coordinator, with an opportunity of extension to permanent full-time based on performance. Artem Nada Lallous 1 , Eric Leblanc 1 , Ravi S N Munuganti 1 , Mohamed D H Hassona 1 , Nader Al Nakouzi 1 , Shannon Awrey 1 , Helene Morin 1 , Mani Roshan-Moniri 1 , Kriti Singh 1 , Sam Lawn 1 , Takeshi Yamazaki 1 , Hans H Adomat 1 , Christophe Andre 2 , Mads Daugaard 1 , Robert N Young 2 , Emma S Tomlinson Guns 1 , Paul S Rennie 1 , Artem Cherkasov 3 May 22, 2017 · Small-molecule drug design is a complex and iterative decision-making process relying on pre-existing knowledge and driven by experimental data. Privacy notice: By enabling the option above, your Dec 1, 2016 · Abstract. Possibilities. load links from unpaywall. (TSX-V: RKV) (“the Company”), a biopharmaceutical company focused on the development of novel DNA-damage response inhibitors (DDRi) to address high unmet medical needs in the treatment of cancer, today announced the appointment of Prof. Aug 8, 2021 · Artem Cherkasov : Artem Cherkasov is a Professor of Medicine at the University of British Columbia (Vancouver, Canada) and a Director of Therapeutics Development at Vancouver Prostate Centre. Featuring news, bio, rankings, playing activity, coach, stats, win-loss, points breakdown, videos Sergey Vladimirovich Cherkasov ( Russian: Сергей Владимирович Черкасов ), also known as Victor Muller Ferreira, [1] is an alleged Russian intelligence officer working for the GRU, whose true identity was revealed by the Dutch General Intelligence and Security Service in 2022. Artem Tcherkassov participated in the Third Vancouver International Mining January 29th, 2014: The Honorary Consul of the Russian Federation Dr. Numerous studies have found that overexpression of Lin28A/B leads to reduced levels of the let-7 members that stimulate tumour cells to gain stemness and invasiveness. edu 7. Availability: The developed HMM-based tools Nov 30, 2021 · The AI program allowed lead investigator Dr. Nov 27, 2023 · About Prof. Artem Cherkasov has screened 40 billion small molecule compounds in 19 days, seeking to find potential drugs to treat COVID-19. I have helped ecommerce companies in DIY, egrocery and fashion to effectively scale operations from 30% to 200% annualy improving unit economics and service levels. An article published this month in Chemical Sciences that includes LSI’s Dr. Cherkasov is a clinical and research scientist at the Vancouver Prostate Dr. Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, 2660 Oak Street, V6H 3Z6, Vancouver Jun 11, 2023 · Variational autoencoders (VAEs) defined over SMILES string and graph-based representations of molecules promise to improve the optimization of molecular properties, thereby revolutionizing the pharmaceuticals and materials industries. Cherkasov’s research interests include artificial intelligence (AI) and computer-aided drug discovery (CADD), structure-activity modelling, drug reprofiling Nov 27, 2023 · About Prof. Studies Samnite Wars, Samnites, and History of Ancient Italy. However, this prior view of the 'und … <link rel="stylesheet" href="styles. The kinds of things that can save lives, make fortunes, and utterly transform the world. The war between the two sides was local in nature, but it was the beginning of a new phase in the development of the Dr. Abstract: Small-molecule drug design is a complex and iterative decision-making process relying on pre-existing knowledge and driven by experimental data. Low-molecular-weight chemicals represent an attractive therapeutic option, as they are readily accessible to organic synthesis and can easily be characteri … Artem Cherkasov is a Professor at the Faculty of Medicine, University of British Columbia and Head of Therapeutics Development Core at the Vancouver Prostate Centre Nov 27, 2023 · (2023-11-27 | TSXV:RKV) Rakovina Therapeutics Welcomes Prof. Senior Research Scientist. A Mar 2, 2021 · The inhibition of the androgen receptor (AR) is an established strategy in prostate cancer (PCa) treatment until drug resistance develops either through mutations in the ligand-binding domain (LBD) portion of the receptor or its deletion. 27, 2023 -- Rakovina Therapeutics Inc. (TSX-V: RKV) (“the Company”), a biopharmaceutical company focused on the development of novel DNA-damage response inhibitors (DDRi) Nov 27, 2023 · VANCOUVER, British Columbia, Nov. Notably, 70% of BCa diagnoses are Estrogen Receptor α positive (ERα+) making it a critical Abstract: Evaluating an effect of one or more perturbations on cells of a first cell type is described. However, these VAEs are hindered by the non-unique nature of SMILES strings May 1, 2007 · As a result, an additional 229 additional AMPs have been identified from Swiss-Prot, and all but 34 could be associated with known antimicrobial activities according to the literature. com, jchaudhary@cau. Cherkasov’s research involves computer-aided drug discovery (CADD), A. However, due to the development of drug resistance and tumor cell survival, a majority of these patients progress to the refractory state of castration-resistant prostate cancer (CRPC). [2] [3] [4] He was first sentenced by a May 30, 2019 · This work encodes multiple SMILES strings of a single molecule using a set of stacked recurrent neural networks, pooling hidden representations of each atom between SMilES representations, and uses attentional pooling to build a final fixed-length latent representation. Aug 3, 2021 · Dr. I have helped ecommerce companies in DIY, foodtech and fashion to effectively scale operations by 2x annualy improving unit economics and service levels and enabling digital transformation. The University of British Columbia. The development of new antiandrogens, such as enzalutamide, or androgen synthesis inhibitors like abiraterone has improved patient outcomes in the treatment of advanced prostate cancer. Artem Cherkasov and his team to sift through 40 billion molecular structures to find about 1,000 with the potential to target SARS-CoV-2, the virus Jun 3, 2019 · Artem Cherkasov Vancouver Prostate Centre, UBC acherkasov@prostatecentre. A number of rather accurate predictions were reported for various binary drug-target benchmark datasets. Head, Chemoinformatic Drug Design. Artem Cherkasov has been awarded a 2021 Distinguished Achievement Award in Excellence in Foundational Science Research, which recognizes outstanding basic science research and scholarly contributions in the areas of health and life sciences. 12 million USD from the DOD Award. Previously, we evaluated the in vitro response of 24 AR mutati … Artem Cherkasov is on Facebook. My current research interests focus on solving fundamental chemical problems with machine…. The Role of Lin28 in Cancers. The final set of 1045 mature peptides and 253 propeptides have been organized into the open-source AMPer database. Art Cherkasov. Some examples include: - Know a lot about capacity management: have expanded own Jun 6, 2017 · Discovery of small molecules that target the DNA-binding ETS domain of ERG protein. In this paper, we discuss (i) the development and evolution of QSAR; (ii by Artem Cherkasov The article is devoted to the first stage of the military confrontation between Rome and the Samnite Federation. Most existing methods for DTI prediction including deep learning models generally have binary endpoints, which could be an oversimplification of the problem, and those methods are typically unable to handle Nov 21, 2023 · Hazem Mslati 1, Francesco Gentile2, Mohit Pandey 1, Fuqiang Ban , Artem Cherkasov 1Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada 2Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, BC, Canada The androgen receptor (AR) is one of the most studied drug targets for the treatment of prostate cancer. Quantitative structure-activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is widely used in computer-aided drug Nov 17, 2021 · Recent explosive growth of ‘make-on-demand’ chemical libraries brought unprecedented opportunities but also significant challenges to the field of computer-aided drug discovery. Using peptide array Congratulations to Drs. His research interests include computer-aided drug discovery (CADD), structure-activity modeling, drug reprofiling, new cancer therapeutics discovery […] Title: Drugging the ‘Undruggable”. The competition in Conscience's CACHE Challenge series, showcases the triumph of open science and collaborative efforts, which differ from the traditional patent-focused approach where scientists operate independently from rival laboratories. 7240489f9455c3f3. LEBLANC Lavinia A. 2 QSAR models find Sep 1, 2020 · Antimicrobial peptides have clear advantages over conventional antibiotics which include slower emergence of resistance, broad-spectrum antibiofilm activity, and the ability to favourably modulate the host immune response. Research summary. Computational prediction of the interaction between drugs and targets is a standing challenge in the field of drug discovery. -guided drug design, cheminformatics, and development of novel, precision cancer Dr. Artem Cherkasov is a Professor of Medicine at the University of British Columbia (Vancouver, Canada) and Head of the Therapeutics Development Core at Vancouver Prostate Centre. Cherkasov is a Professor in the Department of Urologic Sciences, Faculty of Medicine at the University of British Columbia, and Senior Scientist at the Vancouver Prostate Centre and Canada Research Chair in Precision Cancer Drug Design, Rakovina said. Since factors that influence the biological activities of PROTACs are more complex than those of a small molecule drug, we explored a combination of computational chemistry and deep learning strategies to forecast PROTAC activity and Nov 30, 2021 · A team led by Vancouver Coastal Health Research Institute’s Dr. This Analysis describes a Marc B. Artem Cherkasov and Gillian Hanley on being appointed as prestigious Canada Research Chairs. Broad bacterial susceptibility to antimicrobial peptides offers an additional tool to expand knowledge about the evolution Highly motivated professional with 7+ years of experience in product management, operational efficiency and analytics. Dr Artem Cherkasov receives world-wide challenge in drug discovery. The current study represents the first attempt to use virtual screening to identify inhibitors of Artem Cherkasov, North-Caucasus Federal university, Department of foreign history, political studies and international relations, Graduate Student. Recent observations suggest that following years of strong dominance by the structure-based methods, the value of statistically-based QSAR approaches in helping to guide lead optimization is starting to be appreciatively reconsidered by leaders of several larger CADD groups. The functionality of TFs relies on direct protein-DNA interactions, which are notoriously difficult to target with small molecules. Previously, Artem was a Therapeutics Development Head at Vancouver Prostate Centre and also held positions at The University of British Columbia. Natalie Strynadka (Department of Biochemistry and Molecular Biology) and Nov 28, 2023 · Selected Financial Information As at September 30, 2023 $ Cash & cash equivalents: 813,328 Working capital: 990,548 Intangible assets: 4,650,180 Total assets: 5,824,463 Jun 11, 2021 · Resistance to drug treatments is common in prostate cancer (PCa), and the gain-of-function mutations in human androgen receptor (AR) represent one of the most dominant drivers of progression to resistance to AR pathway inhibitors (ARPI). Canadian Institutes of Health Research. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 5f. Qingyuan Feng, Evgenia Dueva, Artem Cherkasov, Martin Ester. Breast cancer (BCa) is one of the most predominantly diagnosed cancers in women. Artem Cherkasov. Patterns. VPC Salary Range: Professional and Technical Staff, Level 5: $46, 804 - $67, 282 per annum. rolfsen@ubc. Erik Rolfsen UBC Media Relations. qy or gm dk jo zo xo eg ir po