Morphea pathology outlines

Morphea pathology outlines. Lymphoid follicles with germinal centers were also noted. While the exact etiology of morphea is not fully elucidated, many studies have explored the immunologic drivers of this disease. However, the clinical presentation, absence of preceding inflammation, induration, or scleroderma and absence of dermal sclerosis on histopathologic examination, led to a diagnosis of LAM. The present study, referred to as the MAC cohort (Morphea in Adults and Children), was designed to examine demographic, clinical, and histological features in a thoroughly-phenotyped cohort of participants with morphea. Solar lentigines are benign lesions occurring on sun- exposed skin. Itching is frequently severe, especially in anogenital area. Oct 24, 2023 · Pigmented purpuric lichenoid dermatitis of Gougerot and Blum. The patient presentation of a small painless mass in a patient in the third - fourth decade is typical. Also called rudimentary meningocele or hamartoma of scalp with ectopic meningothelial elements. The nuclei are ovoid and monomorphic, with occasional mitotic activity. Lasts 3 - 4 weeks, then virus tracks along regional nerves and becomes dormant in trigeminal or other local ganglia. Feb 11, 2022 · Board review style answer #2. Low disease associated death rate; metastases to lung and bone exceptionally rare. Genital aphthosis: 2 points. Subcutaneous fat necrosis of the newborn. Usually in people of African descent, often in earlobe. Due to systemic small vessel leukocytoclastic vasculitis. ICD-O: 9230/0 - chondroblastoma, NOS. [ 1 Jul 8, 2022 · Definition / general. Purpuric skin lesions on extensor arms and legs and buttocks. Many seborrheic keratoses have mutations in FGFR3 (D) but it Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Lichenoid and violaceous plaques with superimposed purpura, 1 to several centimeters in diameter, pruritic, may resemble Kaposi sarcoma, bilateral, chronic. Histologic features are identical to that of BCC occurring elsewhere on the skin. Nevus verrucosus (verrucous epidermal nevus Mar 1, 2020 · Morphea, also known as localized scleroderma, is a sclerosing disease of unknown etiology that involves mainly dermal and subcutaneous. ICD coding. layers of skin. The tumor is composed of basaloid cells and cells with clear cytoplasm. Primary intestinal lymphangiectasia is a rare disorder resulting in lymph leakage into the small bowel lumen and responsible for protein losing enteropathy, leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia ( Orphanet J Rare Dis 2008;3:5 ) May 9, 2019 · Pathophysiology. Lesions on dark skinned individuals may appear as hypopigmentation or have follicular accentuation. We present six cases of morphea in which typical Extrahepatic bile duct nonneoplastic and tumors: biliary intraepithelial neoplasia carcinoma of extrahepatic bile ducts choledochal cyst intraductal papillary neoplasm of biliary tract traumatic neuroma. [Google Scholar] . At puberty, lesions become thicker, more verrucous and hyperpigmented ( Curr Derm Rep 2012;1:186 ) Terms for different clinical patterns. Transmitted by the bite of infected female phlebotomine sandflies (infective stage: promastigotes) Promastigotes phagocytized by macrophages and other types of mononuclear phagocytic cells. Lichen aureus. Peripheral palisading and a thickened basement membrane is noted. Feb 1, 2015 · Historically there has been controversy as to whether Stevens-Johnson syndrome (SJS) is a distinct entity or at the center of the disease spectrum that includes erythema multiforme (EM) and toxic epidermal necrolysis (TEN) Currently, there is an increasing trend for SJS and TEN as representing the ends of a spectrum of severe epidermolytic Sep 21, 2023 · SynopsisCopy. Excoriation may result in partial or full thickness epidermal loss (erosion versus ulcer) Often self induced. ” Pierini and Vivoli later further described it in 1936, suggesting its possible link to morphea. Urticaria pigmentosa: common form of mastocytosis, numerous small yellow brown papules, become hives when rubbed. (J Am Acad Dermatol 2017;76:1124-30. The classic histologic features of allergic contact dermatitis are those of a spongiotic dermatitis. Sep 3, 2020 · Dilated small intestinal lacteals, which may be primary or secondary. Morphea occurs more frequently in women, especially in adults where female predominance is marked (5:1). The absence of antinuclear antibodies (ANA), Raynaud’s phenomenon and capillaroscopic anomalies constitutes an important element of differential diagnosis with systemic Infestations: infestations-general body & pubic louse brown recluse spider cutaneous larva migrans demodex dirofilariasis myiasis onchocerciasis scabies (mite) tick bite Tunga penetrans. Adult Aug 7, 2023 · Atrophoderma of Pasini and Pierini is a rare, cutaneous condition that causes dermal atrophy. Sclerema neonatorum. The cellular infiltrate consist of lymphocytes, plasma cells, and histocytic type cells. Acute: ill defined, oozing, crusted, eroded papules or vesicles on erythematous plaques. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias Apr 4, 2022 · Pathophysiology. It is known to affect the subcutis of the lower extremities, commonly in obese, white women, older than 60. Rare primary mucinosis that presents with nonpitting indurated edema and associated dermal hardening in the absence of any clinical abnormality. Basal cell carcinoma (BCC) arises from the interfollicular or follicular epithelium. Mar 1, 2023 · Definition / general. Similar to that of endometrial endometrioid adenocarcinoma. Nov 20, 2021 · Scleroderma-like disorders include a set of entities involving cutis, subcutis and, sometimes, even muscular tissue, caused by several pathogenetic mechanisms responsible for different clinical–pathological pictures. Promastigotes transform in these cells into the tissue stage of the parasite (i. Differential diagnosis of lichen sclerosus pathology. Jan 8, 2016 · Atrophoderma of Pasini and Pierini is considered an abortive variant of morphea. Linear morphea was the most common morphea subtype (50. Linear morphea participants with deep involvement were more likely to have a limitation in range of motion (28. It is a malignant soft tissue sarcoma with high risk of local recurrence if inadequately excised. Can be associated with secondary infections. Oral psoriasis: red patches, geographic tongue, ulcerations, gingivitis or pustules. The presence of hyperplastic lymphoid follicles in the context of the sclerotic bands of morphea is rarely described. Morphea is not the same as scleroderma (systemic sclerosis), and it does not become scleroderma. Related to meningioma of skin. Mar 13, 2019 · Morphea may present at any age. The pigment is melanin, which is positive with the Fontana-Masson stain but not Prussian blue. Superfical fungal infections may also be found on neoplastic skin lesions. Nov 15, 2021 · Exclude infection. They resist hyaluronidase digestion. Cystitis cystica appears as translucent submucosal cysts, mostly < 5 mm diameter. Fax: 310-794-7005 Phone: 310-825-6911 Email: PLevins@mednet. Usually epithelioid histiocytes, giant cells and sometimes a well formed granuloma. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody Sep 1, 2010 · The two viruses are differentiated by culture (difficult to culture zoster) or immunologic methods. There is a strong female predominance (2-6:1) and most reports have been in Caucasians. Signs: Koebner phenomenon: new psoriatic papules at sites of skin trauma. Contact us at (248) 646-0325 with any questions. Tungiasis: subcutaneous nodules, rashes or ulcer. Also called cold sore. Several types of morphea exist and various Feb 11, 2021 · Psoriatic arthritis: inflammation of distal interphalangeal joints and proximal interphalangeal joints of the feet and hands. Adam Norberg, MS3 - ANorberg@mednet. Skin, left lower leg, shave biopsy: Lichen simplex chronicus (see comment) Comment: Sections demonstrate hyperkeratosis, focal parakeratosis Jun 1, 2013 · Herpes simplex virus. Areas covered: Using PubMed, we performed Morphea (localized scleroderma) is a disease of unknown etiology, presenting as circumscribed areas of indurated skin. 1985; 7:207–221. This diagnostic category is justified because the recurrence and progression rates of papillary urothelial neoplasm of low malignant potential (PUNLMP) are expected to be higher than urothelial papilloma and lower than low grade noninvasive urothelial carcinoma. Z - benign chondrogenic tumors, site unspecified. History of inflammatory bowel disease or inflammatory arthritis. 1097/00000372-198506000-00002. Sep 1, 2012 · Definition / general. Jan 10, 2022 · Morphea profunda or subcutaneous (deep) morphea is a variant of localized morphea, characterized by one or more ill-defined, deep sclerotic plaque. International criteria for Behçet disease - point score system: scoring ≥ 4 indicates Behçet diagnosis ( J Eur Acad Dermatol Venereol 2014;28:338 ) Ocular lesions: 2 points. Clinically, the presence of erosions, oral involvement, a burning sensation or a hyperkeratotic lesional margin favor a diagnosis of lichen planus over lichen sclerosus (Australas J Dermatol 2020;61:324) Sample pathology report. We found the morphea transcriptome is dominated by IFN-γ Mar 16, 2017 · The diagnosis of morphea is often based on characteristic clinical findings. Excoriation: Deep scratch with abrupt loss of epidermis without full thickness loss at an ulcer. Abnormal fibroblast reaction to injury. Preferential sites are the abdomen, trunk, sacral area, or extremities. Most infected adults have latent HSV1 that is activated by upper respiratory infection, excessive exposure to cold, wind, sun, allergies. Page views in 2024 to date: 1,780,751. Histologically, most cases of morphea feature thickened collagen bundles in the deep reticular dermis, sometimes also extending into the superficial dermis or into the subcutis. Most cutaneous mast cell disorders have a good prognosis. Generalized morphea is the most severe form of localized morphea [5, 6]. Dec 7, 2023 · Epidermal nevi typically present as multiple warty brown patches or plaques along the lines of Blaschko. Endometrioid carcinoma is no longer a recognized subtype of HPV associated adenocarcinoma, as it leads to confusion with the usual type. Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma. Over time the patches may become firm, dry and smooth. Panniculitis: alpha-1-antitrypsin deficiency panniculitis calciphylaxis encapsulated fat necrosis erythema induratum (pending) erythema nodosum inflammation should be included in pathology reports to help aid in clinical management. Graft versus host disease (GVHD) is a multisystem immunologic disorder following an allogenic hematopoietic cell transplant and rarely after solid organ transplant or transfusion. 5, colloidal iron, and metachromatic dyes. Jan 30, 2023 · Erosion: Discontinuity of skin causing partial loss of epidermis. Jun 1, 2016 · Lice: intense itching and irritation, erosion, serous crusting and scaling of the scalp or other areas of the body. Histologically, there is a conspicuous bulb-like elongation of rete ridges that Aug 1, 2011 · Palisading, necrobiotic granuloma consist of a large confluent area of necrobiosis centered in the superficial dermis and subcutaneous fat. Cystitis glandularis appears as irregular or nodular lesions with a cobblestone pattern or as a polypoid mass. Pasini described it in 1923 under the name of ”progressive idiopathic atrophoderma. After viral infection, especially UTI or insidious onset with no prior acute illness. Jul 1, 2011 · In adults, is associated with malignancies (lymphoma, carcinoma of bronchus, breast and cervix), sarcoidosis, lupus and drugs. Recurrence rate: 18 - 20% ( Am J Clin Pathol 2010;133:788, Diagn Pathol 2015;10:3 ) Deep morphea encompasses a variety of clinical entities in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle. Overlap can occur where superficial and deep changes co-exist. Morphological features and immunoprofile strongly support the diagnosis of high grade myxofibrosarcoma. In children, the linear subtype predominates while in adults’ plaque and generalized subtypes are most common. Typically affects the interdigital nerve that innervates the third webspace ( Radiographics 1999;19:1253 ) Strong predilection for middle aged women ( Foot Ankle 1983;3:238 ) Characterized microscopically by nerve fiber degeneration and excessive intraneural and perineural fibrosis. Am J Dermatopathol. It is also known as localised scleroderma. Nonpitting, woody induration of upper back skin; associated with diabetes. Index (Alphabetical table of contents) Seborrheic keratosis is a benign keratinocyte proliferation that lacks atypia and dysplasia. Norberg and Levins had full access to all of the data in the study and take responsibility for the integrity of the clinical vignette Jun 22, 2023 · A. Variable elastic fiber changes have been described, but to our knowledge, no systematic study of the elastic fiber pattern correlated with CD34 expression has been reported. Usually HSV1. The overlying epidermis demonstrates hyperkeratosis. Noninvasive epithelial neoplasm of the gallbladder that forms pedunculated polyps composed exclusively of small, nonmucinous tubules, often with squamoid morules ( Virchows Arch 2021;478:435 ) Despite the cytoarchitectural complexity that warrants high grade dysplasia diagnosis, almost never associated with invasion Jun 11, 2021 · Thyroid gland usually 40 g or more. A single-institution retrospective cohort study was conducted. Scalp nodule that often arises during infancy containing meningothelial cells; may be diagnosed later in life. Ichthyosis vulgaris: common type. Morphea profunda. Atrophic lesions: skin is smooth, wrinkled and soft. Positive for Fontana-Masson and CD34. Visceral involvement is most often seen Sep 19, 2022 · Basal cell carcinoma (BCC), previously known as basal cell epithelioma, is the most common cancer in Humans. e1 ) Nulliparous females ( Cancer 1985;56:403, Am J Epidemiol 2008;168:563 ) Oct 20, 2022 · Essential features. Acanthosis and papillomatosis (A) are features of seborrheic keratosis but can also be seen in squamous cell carcinoma. During the early stage of generalized morphea there is an inflammatory reaction involving primarily the fat around the eccrine sweat glands and the subcutaneous tissue. Comment Here. [1] It is an idiopathic, gradually progressive craniofacial asymmetry, following the atrophy of subcutaneous tissue, muscles, osseous, and cartilaginous structures. Affected patients present with single or multiple inflammatory and sclerotic plaques, findings considered manifestations of active disease. PathologyOutlines. Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. com, free, updated outline surgical pathology clinical pathology Abstract. Familial cases have been described. Usually caused by dermatophytes; in children, usually due to Trichophyton Differentiate metastatic colorectal adenocarcinomas (SATB2+) from pancreatobiliary neoplasms (SATB2-) ( Am J Clin Pathol 2021;155:124 ) Differentiate ovarian metastases of colorectal and appendiceal origin (SATB2+) from primary ovarian tumors of mucinous or endometrioid type (SATB2-) ( Am J Surg Pathol 2016;40:419 ) May 17, 2022 · Tumor cells show focal SMA and CD34 positivity, whereas desmin, caldesmon, S100 and pancytokeratin are negative. Morphoea (American spelling, morphea) is characterised by an area of inflammation and fibrosis (thickening and hardening) of the skin due to increased collagen deposition. Eosinophilic, swollen or degenerate collagen appears hyalinised with surrounding infiltrate of lymphocytes and histiocytes. Oct 18, 2021 · Sheets of chondroblasts admixed with osteoclast-like giant cells and eosinophilic chondroid matrix; pericellular chicken wire type calcification may be present. We present a 26-year-old Caucasian female with a 1. The spectrum ranges from relatively mild phenotypes, which generally cause few problems besides local discomfort and visible disfigurement, to subtypes with severe complications such as joint Mar 9, 2023 · Soft tissue, neck, biopsy: Nodular fasciitis (see comment) Comment: This is a spindle stellate cell neoplasm arranged in short bundles and fascicles. X linked variant: deficiency in steroid sulfatase, which removes proadhesive Sep 1, 2012 · Definition / general. The tumor cells are typically diffusely positive for CD34 but negative for factor XIIIa. Basal cell carcinoma (BCC) arises from epithelial cells of either epidermis or hair follicle stem cells. The following clinical diagnostic criteria for this subtype of morphea must be fulfilled: four or more lesions larger than 3 cm in diameter or involvement of two or more of the seven body areas (the head and neck, the right and left upper extremities, the anterior and posterior trunks, and the right and left lower Jan 30, 2024 · Definition / general. This is an example of pigmented dermatofibrosarcoma protuberans (Bednar tumor). Nevus sebaceus of Jadassohn (sebaceous nevus, organoid nevus) is a hamartoma that is histologically characterized by a complex and abnormal proliferation of epidermis and adnexal structures. Specific conditions Erythema nodosum General. Mucin types include acid mucins and neutral mucins. Extensive on the scalp. 5-year history of linear Scleroderma panniculitis, also morphea profunda. Nov 1, 2019 · Microscopic description: A folliculocentric tumor with bulbous profile and stromal clefting is seen in the dermis with connection to the epidermis. Scleroderma: In this condition the overlying epidermis and superficial dermis is spared. Epidermal nevi can form a linear or zosteriform lesion. Telangiectasia macularis eruptive perstans (TMEP): telangiectatic light or dark brown macules. Adenomatoid tumors rarely involve the testicular parenchyma and are the most common paratesticular tumor. Linear morphea en coup de sabre is a localized form of morphea that presents as paramedian face or frontal scalp depression. Atrophoderma of Pasini and Pierini usually first appears in adolescence or early adulthood (second and third decade). Local aggressive course. Introduction: Morphea is a chronic autoimmune fibrosing condition of the skin and underlying tissue with the potential for significant disease-associated morbidity. Jul 1, 2013 · In the present study, secondary alopecia was seen in 8 cases, of which there were 4 cases of morphea and one each case of lupus vulgaris, congenital absence of skin, burn and sarcoidosis. True endometrioid carcinoma of the cervix is exceedingly rare and likely arises from cervical endometriosis. Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Superpages: entire chapter images virtual slides. See full list on cme. Presence of multiple epidermal inclusion cysts has been documented in Gardner syndrome , a variant of familial adenomatous polyposis with benign osteomas and intestinal fibromatoses. Most common malignant tumor type in humans. Age: fourth to sixth decades (peak fifth) Increased circulating estrogen: Body mass index (BMI): dose response relationship of BMI ≥ 25 and risk of hyperplasia ( Am J Obstet Gynecol 2016;214:689. Histologic features are similarly variable, and skin biopsies may be nondiagnostic. Eosinophilic Fasciitis. Gallbladder stains: CK7 CK19 CK20 DPC4 / SMAD4. The stroma is variably myxoid to collagenous, with scattered lymphocytes and extravasated erythrocytes. History of papule, pustule, vesicle within 4 days of ulceration. Rusty yellow or gold lichenoid papules, patches and plaques, unilateral, acute onset, persistent course. , amastigotes) Parasite, host and other factors affect Morphea, or localized scleroderma, is a rare disease of the connective tissue that manifests itself with localized sclerosis of the skin and, in some cases, with extracutaneous manifestations. Case 1: Superficial morphea: A 28-year old female with hyper- and hypopigmented atrophic, painful, shiny patches in the bilateral intertriginous areas. Case 2 —A 45-year-old male presented with a 1-year history of hyperpigmentation around the neck and lower face, which worsened with sweating and during summer. 1%, 291/581) in the cohort. Associated anti-SSA / Ro autoantibodies (40 - 100%); anti-SSB / La antibodies are often present as well. Drug induced in 30% of cases ( Br J Dermatol 2012;167:296 ) Jul 21, 2015 · Takei Y, Fukushiro S, Ackerman AB. Jul 1, 2011 · Definition / general. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtypes according to the clinical presentation and depth of tissue involvement. Other nonneoplastic lesions: calcification ectopic decidual reaction endometriosis endosalpingiosis cortical inclusion cyst polycystic ovary disease torsion. Jul 1, 2011 · Primary amyloidoisis: masses of eosinophilic, amorphous, fissured material in dermis and subcutaneous tissue. BCC mostly arises on sun-damaged skin and rarely develops on the mucous membranes or palms and soles. Most common from of panniculitis. White, flat topped papules, plaques or atrophic patches. Healing is associated with postinflammatory hyperpigmentation. Found in epithelium (gallbladder [benign, adenocarcinoma], intestinal metaplasia in stomach) Positive for PAS, Alcian blue at pH 2. K36M mutations commonly identified. Onset in infancy, childhood, and late adult-life has been reported, as has congenital presentation. Multinodular goiter: irregular enlargement of thyroid gland due to repeated episodes of hyperplasia and involution (degeneration) of simple goiter. Epidemiology. Subacute cutaneous lupus erythematosus (SCLE) presents clinically as a photosensitive, nonscarring, nonatrophy producing eruption. Vulvar BCC is rare. It is also known as scleroderma panniculitis . But they might also appear on your face, arms and legs. Address: UCLA Med-Derm 200 Medical Plaza, Suite 450 Los Angeles, CA 90095. Erythema induratum. Lupus panniculitis. Alpha1-antitrypsin deficiency. 1 This disease is characterized by sclerosis of the skin and subcutaneous tissue, resulting from chronic inflammation and deposition of collagen and extracellular matrix proteins. Lobular: Infectious panniculitis. Neurological manifestations: 1 point. lww. Morphea profunda is a type of panniculitis. Skin lesions: 1 point. Morphea profunda, eosinophilic fasciitis, and disabling pansclerotic morphea of children are included in this group, but overlapping of the extent and depth of cutaneous involvement Feb 3, 2021 · Fig 1. Superficial dermal perivascular mononuclear and eosinophilic infiltrate. Pathergy. In our patient, the initial clinical diagnosis was linear morphea. Although rarely fatal, BCC can be highly destructive and disfigure local tissues when treatment is Clement: Atlas of Gynecologic Surgical Pathology, 4th Edition, 2019, Surg Pathol Clin 2019;12:249 Board review style question #1 The image above shows an example of HPV independent squamous cell carcinoma of the vulva in association with differentiated vulvar intraepithelial neoplasia. Lamellar ichthyosis: rare inherited skin condition of newborn with shedding of plate-like layers of skin. 1%, 11/99, P < . 001). The pathogenesis of morphea is not fully understood, but autoimmune dysfunction and imbalance of collagen Definition / general. doi: 10. The inflammatory infiltrate is typically sparse and around deep adnexal and vascular structures. Morphea patients who had a biopsy in 2005–2015 were included, and a histopathological review was conducted by 2 Oct 10, 2023 · Definition / general. 3%, 187/291) than other morphea subtypes. These plaques eventually become inactive, leaving permanent dermal or soft Mar 2, 2021 · Diagnosis. Eventually converts into multinodular goiter. edu. Paul Levins, MD. We sought to examine the molecular landscape of morphea by examining lesional skin gene expression and blood biomarkers and comparing the gene expression profiles with those from site-matched nonlesional and SSc lesional skin. Typically, the skin changes appear on the belly, chest or back. 2, 3 Because morphea can lead to substantial morbidity Abstract. Spongiotic dermatitis. Read more >>. Apr 5, 2023 · Morphea is an inflammatory fibrotic disorder of the skin that has been likened to systemic sclerosis (SSc). Subacute: thickened, scaly or excoriated plaques. High rate of recurrence after excision. Pathogenesis is related to repeated intermittent sun exposure and ultraviolet-induced mutations leading to enhanced melanin production and abnormal pigment retention by keratinocytes. Aug 25, 2022 · Morphea (mor-FEE-uh) is a rare condition that causes painless, discolored patches on your skin. ) Key words: morphea; pain; pathology; sclerosis; severity; symptoms. D. Acid mucins: Acid-simple non-sulfated: Contain sialic acid. Jul 1, 2011 · Eosinophilic infiltration of hair follicle; follicular epithelium is spongiotic, adjacent dermis has lymphocytic and eosinophilic infiltrate. ucla. Herpes simplex: Historically, HSV1 was associated with herpes labialis (90%), and HSV2 was associated with herpes genitalis (90%), although in some recent studies, most genital lesions are caused by HSV1. Definition / general. Its etiology is not fully understood, but it is believed that there is genetic predisposition, in addition to environmental triggering factors. Tumor-like lesions: corpus luteum cyst fibromatosis and massive edema follicle cyst hyperreactio luteinalis large solitary luteinized follicular cyst of pregnancy and puerperium Leydig Nov 8, 2022 · Parry Romberg syndrome (PRS), also referred to as progressive hemifacial atrophy, progressive facial hemiatrophy, or idiopathic hemifacial atrophy, was first described by C Parry and M Romberg. Healed ulcer site with wrinkled paper scar. Due to pathogens restricted to the stratum corneum, with little or no tissue reaction. Atypical mitotic figures (B) are a feature of squamous cell carcinoma. Nov 10, 2020 · Mucosa may appear grossly unremarkable. Also abdominal pain, vomiting, GI bleeding, arthralgias, hematuria, proteinuria and nephrotic syndrome. Helminths: subcutaneous nodules, rashes or ulcer. References: Pathol Annu 1995;30:95, Histopathology 2011;58:811. 7 per 100,000 individuals. Jul 1, 2021 · Morphea (localized scleroderma) is a rare fibrosing disorder of the skin and underlying tissues, with an estimated incidence of 2. However, full-thickness skin biopsies, containing fascia and muscle tissue, are required for the diagnosis of EF. Multiple ulceration, at least 1 on anterior lower leg. e. Histopathological evaluation of skin biopsies and laboratory tests are not necessary in the majority of morphea cases. Thyroid gland often 100 g or more; may resemble a neoplasm, particularly if a single firm dominant nodule is present. ICD-11: 2E82. In chronic longstanding allergic contact dermatitis, there can also be psoriasiform changes with marked acanthosis and lesser degrees of spongiosis. May be surrounded by an erythematous to violaceous halo. Scalp and beard lesions may have superimposed bacterial folliculitis / perifolliculitis. Plaque morphea is characterized by ivory-white oval lesions with a lilac peripheral ring and a smooth surface asymmetrically distributed on the trunk or, less commonly, on the extremities; the face and fingers Definition / general. It can be acute or chronic and can affect many organ systems, including the skin, gastrointestinal tract, liver and lungs. Need clinical history to distinguish between renal limited IgA nephropathy and systemic HSP. Lipodermatosclerosis (hypodermitis sclerodermiformis and sclerosing panniculitis) presents as a chronic fibrosing disease commonly associated with venous insufficiency, arterial ischemia or thrombophlebitis. Background: Scleroderma/morphea is characterized by expansion of the dermis with thickened collagen bundles and loss of CD34 (+) dermal dendrocytes. Nov 2, 2021 · Gastric type and clear cell carcinomas are known to be HPV independent. com Nov 11, 2020 · Morphea (localized scleroderma) is a rare fibrosing disorder of the skin and underlying tissues, with an estimated incidence of 2. Pancreatic panniculitis. Peripheral erythema, undermining border and tenderness. Deep involvement was more common in linear (64. Oral aphthosis: 2 points. We are proud of the numerous testimonials we receive, both from pathologists and advertisers. Follicular orifice becomes plugged with bacteria and keratin, leading to cystic dilation and entrapment of keratin debrisÂ. Jan 28, 2020 · This is an adenomatoid tumor, which is of mesothelial origin as the staining pattern suggests. Lichen planus: The presence of a well Supplementary concepts. Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. M orphea (localized scleroderma) is char-acterized by thickening of the skin re-sulting from inflammation and the Morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both. 6%, 55/192) than those without (11. ICD-11: XH4NK2 - chondroblastoma, NOS. Mastocytosis: monomorphic population of mast cells with rare eosinophils. Clinically manifests as a congenital, yellow-orange mamillated patch / plaque with alopecia typically occurring on the scalp and face. Subtypes of morphoea vary according to the Nov 20, 2021 · Morphea, also known as localized scleroderma, manifests with single or multiple areas of cutaneous sclerosis, with varying morphology. Atopic dermatitis may be categorized depending on the phase of the disease. Home page (desktop + mobile): Page views in 2023: 4,952,237. Dysuria, urethral and vaginal discharge, dyspareunia, burning pain, fissuring and erosion may occur. It manifests in the first two decades Sep 7, 2023 · Morton neuroma is a degenerative fibrotic neuropathy. Lichenoid amyloidosis: hyperkeratosis, acanthosis, basal hydropic degeneration; small eosinophilic globules in Mar 5, 2024 · Morphea, also known as localized scleroderma, is an idiopathic inflammatory disorder that causes sclerotic changes in the skin. Basal cell carcinoma is usually a slow-growing tumor for which metastases are rare. The histopathology of alopecia in linear morphea is typically characterized by sclerosis and a reduction in the number of follicular units. Morphea is a cutaneous fibrosing connective tissue disorder that represents a localized form of scleroderma (or systemic sclerosis) occurring primarily in children aged 2-14 years and in women in the fifth decade of life. In 2001, a group of hair clinicians, pathologists and researchers, under the rubric of the North American Hair Research Society (NAHRS), issued a consensus Definition / general. Macular amyloidosis: focal / small amounts of eosinophilic faceted deposits in papillary dermis; also pigment incontinence. Follicular mucinosis may rarely be seen. Dec 7, 2023 · Clinical features. Morphea is an autoimmune skin disease with protean clinical manifestations. Morphea tends to affect only the outer layers of your skin. The term 'scleroderma' covers various types of morphoea and systemic sclerosis . Erosions may progress to become open, non healing wounds and Solar lentigo. It presents as single or multiple, sharply demarcated, hyperpigmented, non-indurated patches with no obvious Aug 1, 2011 · Definition / general. td ob eg ry ix ti kt cz es qy